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| 1850 |
| | The brothers James and John Harper launch in New York Harper's Monthly Magazine, still published today | |
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| 1850 |
| | As many as 50,000 US pioneers travel west this year on the Oregon Trail | |
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| 1850 |
| | California is admitted to the union just two years after being acquired from Mexico | |
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| 1850 |
| | The slave trade, but not slavery itself, is banned in Washington and the district of Columbia | |
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| 1850 |
| | Brazil, historically the world's second largest importer of slaves from Africa, finally bans the slave trade | |
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| 1850 |
| | US president Zachary Taylor dies after a short illness and is succeeded by his vice-president, Millard Fillmore | |
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| 1850 |
| | The US Congress passes the Compromise of 1850, designed to defuse the growing crisis over slavery | |
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| 1850 |
| | The Fugitive Slave Act, concerned with the arrest of runaway slaves, is the most contentious part of the Compromise of 1850 | |
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| 1850 |
| | Nathaniel Hawthorne publishes his novel The Scarlet Letter, in which Hester Prynne is forced to wear the letter A for Adultress | |
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| 1850 |
| | US Secretary of State John Clayton and British ambassador Henry Bulwer come to an agreement about the building of a canal between the Atlantic and Pacific | |
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